Six new Indo-Pacific Cardiidae species are described originating from various institutional collections, supplemented with material from private collections, mostly based on shell characters and partly augmented by genetic information: Microcardium lukasi spec. nov., Microcardium roelofi spec. nov., Ctenocardia lisae spec. nov., Acrosterigma zamboangaense spec. nov., Vasticardium jorgeni spec. nov. and Vasticardium albopacificum spec. nov. A new subfamily Nemocardiinae subfam. nov. is proposed for the genera Nemocardium Meek, 1876; Pratulum Iredale, 1924; Keenaea Habe, 1951; Lophocardium P. Fischer, 1887; Frigidocardium Habe, 1951 and Microcardium Keen, 1937. In addition it comprises the extinct genera Anechinocardium Hickman, 2015 and Arctopratulum Keen, 1954. Some notes are given on the composition and geographic distribution of the Vasticardium elongatum group of species. Acrosterigma elongatum cipangense J. Vidal, 1993 is considered a junior synonym of Trachycardium (Acrosterigma) serricostatum okinawaense Kuroda, 1960 and Vasticardium kuboderai Thach, 2015 a junior synonym of Vasticardium berschaueri Thach, 2014.